How common are Lexapro side effects?
Direct Answer
The most common Lexapro side effects are nausea (up to 18%), headache (24%), insomnia (9-14%), drowsiness (6-13%), and sexual dysfunction (reported by 2-16% in trials, though real-world rates may be higher). Most side effects are worst in the first 1-2 weeks and improve as your body adjusts. Sexual side effects (decreased libido, difficulty with orgasm) are the main reason people want to stop SSRIs and tend to persist throughout treatment. Lexapro is generally considered one of the better-tolerated SSRIs, with fewer drug interactions than many alternatives.
Based on published clinical trial data and FDA prescribing information. This is not medical advice — always consult your healthcare provider.
Supporting Evidence
Side Effects
Serious (rare)
- Suicidal ideation (under-25, first weeks)
- Serotonin syndrome
- QT prolongation / cardiac arrhythmia
Clinical Trials
Response 50-60%, remission 35%; slightly better tolerated than most SSRIs
Funding transparency: Lundbeck funded most original trials. Publication bias prominent in antidepressant literature. FDA analysis showed smaller effects than published studies. See full funding details
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