Supporting MAHA ELEVATE
With Transparent Medication Data.
EvidentMeds is a free, citation-backed medication evidence directory with clinical trial funding disclosed, lifestyle alternative evidence ratings, and pharmacogenomics context - built to support the kind of evidence-driven care ELEVATE promotes.
What Is CMS MAHA ELEVATE?
Make America Healthy Again - Evaluating Lifestyle, Education, and Verified Alternative Treatment Efficacy is a CMS initiative funding 30 community health organizations to rigorously test whether structured lifestyle interventions can reduce chronic disease burden. The program launches September 2026.
30 CMS Awardees
Community health organizations testing structured lifestyle interventions alongside evidence-based medication optimization
Evidence-Driven
Programs must demonstrate measurable outcomes, reduced HbA1c, weight loss, medication optimization, improved biomarkers
Pro-Evidence, Not Anti-Medication
ELEVATE is about ensuring every prescription is justified by evidence, and every lifestyle intervention is grounded in data
Evidence Brief Generator
Search for a specific medication or select a condition to generate a data-driven evidence brief. Each brief pulls real cost, efficacy, side effect, and lifestyle alternative data from our directory.
Pre-diabetes / Metabolic Syndrome
Evidence Brief for MAHA ELEVATE Program Design - 4 medications analyzed
Medications - Cost, Efficacy & Lifestyle Alternatives
Low-carb diet: Comparable A1C reduction to metformin
Weight loss (5-10%): -0
Exercise: Improves insulin sensitivity 48-72h per session
Very low-carbohydrate diet (<50g/day) - Strong
Mediterranean diet - Strong
Resistance training (3×/week) - Strong
Ketogenic Diet (<20g net carbs/day): HbA1c -1
Time-Restricted Eating (16:8 or OMAD): Improves fasting insulin, HbA1c, and visceral fat independently of caloric restriction
Resistance Training (3×/week): Increases GLUT4 transporter density in muscle; glucose disposal increases 48%; HbA1c improves independently of weight loss; reduces visceral adipose tissue
Low-carbohydrate diet - Strong
Intermittent fasting (16:8 or 5:2) - Strong
Mediterranean diet - Strong
Ketogenic Diet (<20g net carbs/day): HbA1c reduction 1
Resistance Training (3×/week): Increases GLUT4 transporter density; glucose disposal increased 48%; improvements persist 48–72 hours per session
Time-Restricted Eating (16:8): Improves fasting insulin, HbA1c, and visceral fat independently of caloric restriction
Carbohydrate Restriction (<50g/day): Low-carb diets achieve HbA1c reductions of 0
Structured Exercise (Aerobic + Resistance): Regular exercise improves eGFR, reduces proteinuria, and lowers blood pressure 5–10 mmHg, addressing both diabetic and CKD endpoints simultaneously
DASH Diet for Hypertension/CKD: DASH diet reduces systolic BP 8–14 mmHg; in CKD patients, blood pressure control is the single most important factor in slowing progression
Key Studies Referenced
UKPDS (gold standard), DPP, Cochrane meta-analysis · SUSTAIN-1 through SUSTAIN-10, PIONEER, SELECT, STEP program · EMPA-REG OUTCOME (2015), EMPEROR-Reduced (2020), EMPEROR-Preserved (2021) · DECLARE-TIMI 58 (2019), DAPA-HF (2019), DAPA-CKD (2020)
Full medication profiles include clinical trial funding sources, side effect rates, tapering protocols, pharmacogenomics data, and comprehensive alternative evidence ratings.
Frequently Asked Questions
What is CMS MAHA ELEVATE?
MAHA ELEVATE (Make America Healthy Again, Evaluating Lifestyle, Education, and Verified Alternative Treatment Efficacy) is a CMS initiative funding 30 community health organizations to test whether structured lifestyle interventions can reduce chronic disease burden. The program launches September 2026.
How does EvidentMeds support MAHA ELEVATE?
EvidentMeds provides a free evidence layer that directly aligns with ELEVATE's mission: transparent, citation-backed medication profiles with clinical trial funding disclosed, lifestyle alternative evidence ratings, and pharmacogenomics context. ELEVATE awardees and applicants can use these tools to build evidence-driven program designs and support deprescribing decisions with real data.
Is EvidentMeds anti-medication?
No. EvidentMeds is pro-evidence. Many medications are life-saving and irreplaceable. Our role is to ensure clinicians and patients have transparent access to clinical trial data, funding sources, and lifestyle alternatives, so treatment decisions are informed, not influenced by marketing. We follow the evidence wherever it leads.
How can we partner with EvidentMeds?
We'd love to explore how EvidentMeds can support MAHA ELEVATE awardees and applicants. Contact Solutions 2 Wellness, LLC at info@solutions2wellness.org to start a conversation about how we can help.
Let's Explore How We Can Help
We built EvidentMeds to support evidence-driven care, and MAHA ELEVATE represents exactly that mission. If you'd like to explore how this resource can support ELEVATE awardees or applicants, we'd welcome the conversation.
The Evidence Layer for MAHA ELEVATE.
Explore transparent medication profiles, generate evidence briefs, and reach out when you're ready to connect.