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Can you take Advil® / Motrin® with Cozaar®?

Evidence-based interaction check between Advil® / Motrin® and Cozaar®

MajorEditorially reviewed · last updated April 15, 2025

High risk — avoid this combination unless there is no good alternative.

Acute kidney injury, blunted blood-pressure control, and rising potassium. Same 'triple whammy' risk as ACE inhibitor + NSAID + diuretic.

Why this happens (mechanism)

ARBs (like losartan) and NSAIDs both alter blood flow inside the kidney from opposite directions — the ARB widens the outflow vessel, the NSAID narrows the inflow vessel. The combination can shut down filtration, especially in volume-depleted or older patients.

What to monitor

  • Serum creatinine and potassium 1-2 weeks after regular NSAID use begins
  • Blood pressure trend
  • Hydration status, especially in heat or with GI illness

Dose adjustment

Do not adjust losartan; reduce or eliminate the NSAID where possible. If both must continue, monitor labs more frequently.

Safer alternatives to consider

Acetaminophen (Tylenol)

Does not affect renal blood flow or potassium handling.

Topical NSAID

Lower systemic NSAID load for local joint pain.

Always discuss alternatives with your prescriber before making any change. The right choice depends on your other medications, conditions, and what is working for you today.

Evidence and sources

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Check another pair

2 interactions found

Moderate

NSAIDs blunt blood pressure reduction and increase acute kidney injury risk, especially problematic in elderly or dehydrated patients.

Moderate

Reduces blood pressure effect; increases kidney injury risk

View Advil® / Motrin® View Cozaar®

What this means

This summary is based on published interaction data from FDA prescribing information and clinical literature. It does not account for individual health factors, dosages, or other medications you may be taking. Always consult a qualified healthcare provider before making changes to your medication regimen.

Frequently Asked Questions

Is it safe to take Advil® / Motrin® with Cozaar®?

High risk — avoid this combination unless there is no good alternative. Acute kidney injury, blunted blood-pressure control, and rising potassium. Same 'triple whammy' risk as ACE inhibitor + NSAID + diuretic. Always discuss your full medication list with your prescriber.

What happens if you take Advil® / Motrin® and Cozaar® together?

ARBs (like losartan) and NSAIDs both alter blood flow inside the kidney from opposite directions — the ARB widens the outflow vessel, the NSAID narrows the inflow vessel. The combination can shut down filtration, especially in volume-depleted or older patients.

What should I monitor if I take both?

Serum creatinine and potassium 1-2 weeks after regular NSAID use begins. Blood pressure trend. Hydration status, especially in heat or with GI illness.